ARThritis In Synovial Tissue (ARTIST)
Brief description of study
The research study is being conducted to better understand the role of immune cells in the development of joint inflammation in patients with inflammatory arthritis and to identify immune predictors in tissue and fluid from joints and blood that can be used in the clinic to assign the best therapy for a rheumatologic patient.
Detailed description of study
We will obtain joint tissue by a minimally invasive ultrasound guided synovial tissue biopsy, joint fluid by a standard bedside procedure, and/or blood through standard venipuncture from patients with inflammatory arthritis, osteoarthritis, and healthy subjects.
Eligibility of study
You may be eligible for this study if you meet the following criteria:
- Conditions: Medical Research
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Age: 18 years - 99 years
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Gender: All
Participant inclusion criteria for patients:
- Have a diagnosis of inflammatory arthritis or osteoarthritis
- Are at least 18 years old at the time of consent
- Recent laboratory testing within the last 4 weeks with
- hemoglobin ≥ 8 g/dL
- platelets ≥ 100x10<span class="s3">9</sup> cells/L
Participant inclusion criteria for healthy volunteers:
- Are at least 18 years old at the time of consent
- Recent laboratory testing within the last 4 weeks with
- hemoglobin ≥ 8 g/dL
- platelets ≥ 100x10<span class="s3">9</sup> cells/L
Participant exclusion criteria for patients and healthy volunteers:
- Pregnant or lactating women
- Active infections such as hepatitis, pneumonia, pyelonephritis or chronic skin infections based on chart review and/or patient report
- History of bleeding disorder based on chart review and/or patient report
- History of infection with human immunodeficiency virus (HIV), hepatitis B, or untreated hepatitis C based on chart review and/or patient report
- Soft tissue, or intra-muscular corticosteroid injections during the 4 weeks prior to screening based on chart review and/or patient report
- Corticosteroid injection into joint to be biopsied (within 8 weeks) based on chart review and/or patient report
- Previous arthroplasty on the target joint based on chart review and/or patient report
- Current use of warfarin, clopidogrel or other anticoagulant based on chart review and/or patient report
- Are allergic to lidocaine based on chart review and/or patient report
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