Adult Virome Study | Clinical Research Studies Listing

Recruiting

99 years or below

All

Phase N/A

100 participants needed

1 Location

Brief description of study

Did you know that all of us, including all healthy people, have viruses in our bodies that do not make us sick but actually may contribute to health? Researchers are exploring the viruses that exist in people that are not currently sick in order to understand their role in human health. Samples will be taken from the nose, mouth, blood, and stool. Some people will also have sampling of the lungs. Participants will be asked to come in for 1-2 sampling visits at Penn Presbyterian every 12-15 months over the span of 3-4 years.

Detailed description of study

Aim 1. Leverage existing biobanked oral, gut, respiratory tract and blood specimens of generally healthy adults for immediate initiation and scale-up of cross-sectional and archived longitudinal sample virome characterization.

Aim 2. Access and re-enroll participants from previously-established cohorts, including those linked to the existing biobanks, for prospective virome sample collection and characterization with clinical phenotyping for expanded body site and extended longitudinal sample analysis.

Aim 3. Implement high quality sample collection, including high stringency collection with key controls and reference samples in challenging biological niches, to ensure optimal rigor and reproducibility through valid, authentic representation of targeted sites, along with optimal handling and storage.

Aim 4. Collaborate with the Biospecimen Analysis Core and the Analysis & Submission Cores to link virome data to clinical and sample collection metadata; with the Ethical Legal & Social Implications Core to ensure rigorous ethics of participant involvement, data use and studies relevant to human virome research; and with other VCCs within the HVP program to provide integrated cross-center virome analysis to amplify scale and impact. Learn more about the virome and the role it plays in the human body. Master the methods development to increase the ability to identify more of the virome through precise validation and sequencing.

Eligibility of study

You may be eligible for this study if you meet the following criteria:

Conditions: Medical Research, healthy volunteers, healthy participants
Age: 99 years or below
Gender: All

over the age of 18
no major medical conditions
living in the Philadelphia area for the next 3-4 years or willing to return for requested study visits

Updated on 10 Aug 2026. Study ID: 24-1577

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