SCD Depo | Clinical Research Studies Listing

Recruiting

18 years - 50 years

Female

Phase N/A

65 participants needed

1 Location

Brief description of study

The Women's Health Clinical Research Center at Penn Medicine is conducting a paid research study to see if women with sickle cell disease (SCD) experience any pain differences while using the birth control injection known as Depo, as compared to when not using it. Depo-Provera is already FDA-approved, safe to use, and lasts for 3 months.

The study duration is 6 months, with 6-7 in-person visits that include a urine pregnancy test, blood draw, and surveys. Participants will also complete weekly surveys asking about pain and their menstrual cycle, and will be compensated up to $715 for completing all parts of the study. In-person visits will be conducted at 3737 Market Street, Philadelphia, PA.

We are seeking women who are between the ages of 18 and 50 who have been diagnosed with SCD, have a regular menstrual cycle, and experience at least one vaso-occlusive pain episode per month.

Eligibility of study

You may be eligible for this study if you meet the following criteria:

Conditions: Sickle Cell Disease, SCD
Age: 18 years - 50 years
Gender: Female

Seeking participants who are/have:

Female, aged 18-50 years old
Diagnosis of sickle cell disease (SS, SB0,SB+,SC)
Report of at least 1 vaso-occlusive pain episode per month on average in the previous 6 months
Willing to discontinue any hormonal contraception at the time of enrollment.
Have regular menstrual cycles (when not on hormonal contraception) with a usual length of 21 to 35 days.

Updated on 03 Aug 2026. Study ID: 24-1745

Find a site

Your Information has been sent successfully.

We have submitted the contact information you provided to the research team at {{SITE_NAME}}. A copy of the message has been sent to your email for your records.

Would you like to be notified about other trials? Sign up for Patient Notification Services.

Send a message

Enter your contact details to connect with study team

View email

Phone

View phone

First name*

Last name*

Email*

Phone number*

Preferred way of contact

Please provide your preferred way of contact

Other language

By Submitting your information, you agree that your details may be shared with the selected study site and handled in accordance with this Website's Privacy Policy (see link in footer). You may be contacted by email, text message, or phone regarding this study and other research opportunities that may be of interested to you. You can unsubscribe from these communications at any time. Message and data rates may apply.

Interested in the study

Select a study center that’s convenient for you, and get in touch with the study team.

Contact a study center