NEUROBIOLOGICAL CORRELATES OF AUTOBIOGRAPHICAL MEMORY TRAINING TO IMPROVE

Recruiting

18 years - 60 years

All

Phase N/A

30 participants needed

1 Location

Brief description of study

The study is being conducted with healthy control individuals and people with opioid use disorder (OUD) to better understand brain and memory functioning in people with OUD. The study will test whether a 4-week memory training intervention (Memory Flexibility Training) improves memory in people with OUD.

Detailed description of study

If you agree to join the study, you will be asked to complete the following research procedures:

Consent/Screening Visit: You will complete a medical history/physical exam with a clinician, urine drug screen, and questionnaires to determine eligibility.
Baseline Assessment Visit: This visit consists of questionnaires and a set of computerized tasks. During the tasks, we will measure your brain activity using functional near-infrared spectroscopy (fNIRS) and measure your heartbeats with a wristband sensor. A researcher will guide you through the first session of Memory Flexibility Training (MemFlex).
MemFlex and 3 Weekly Visits (participants with OUD only): For four weeks, you will complete two 30-minute MemFlex sessions per week at home. You also will come to our center once per week for 3 weeks to provide a urine drug screen and complete questionnaires. For each MemFlex session, you will learn about types of memory and complete memory practice exercises. For these exercises, you see memory prompts and practice recalling details of positive and neutral memories from your life. Sessions will build on each other to help you develop easier access to these memories.
Follow-up Assessment Visit: Four weeks after the baseline visit, you will again complete questionnaires and computer tasks, during which we will again measure your brain activity (with fNIRS) and heartbeat (with a wristband sensor).

Eligibility of study

You may be eligible for this study if you meet the following criteria:

Conditions: Opioid Use Disorder
Age: 18 years - 60 years
Gender: All

Key Inclusion Criteria

Willing and able to attend each study visit and have access to a cellphone for communication.
OUD participants: history of opioid use disorder.

Key Exclusion Criteria

Severe psychiatric or medical condition that would interfere with completion of the study or intervention.
Current participation in a research study or recent participation in a clinical trial and receipt of investigational drug(s).
Currently prescribed opioid medication for treatment of pain or other disorder (besides opioid use disorder).
OUD participants: Positive urine drug screen except for opioids, cocaine, and cannabis at screening or the baseline assessment visit.
HC subjects: Positive urine drug screen for any tested substances at screening or the baseline assessment visit.

Updated on 27 Apr 2026. Study ID: 24-1579

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