iTBS for emotion regulation in bipolar | Clinical Research Studies Listing

Recruiting

22 years - 65 years

All

Phase N/A

68 participants needed

1 Location

Brief description of study

The research study is being conducted to examine the effects of accelerated intermittent theta-burst stimulation (aiTBS), a form of transcranial magnetic stimulation, to the inferior parietal lobe (IPL) in a sample of BD patients who are currently depressed. This project will recruit patients aged 22-65 with symptoms of bipolar depression who have failed (or not shown signs of improvement) after at least one prior treatment.

Detailed description of study

Participants will undergo two fMRI scans, one before and one after the intervention. They will complete a total of 24 sessions over 4 days, with 6 sessions per day. Participants will be randomized to receive either sham or real TMS.

Eligibility of study

You may be eligible for this study if you meet the following criteria:

Conditions: Medical Research
Age: 22 years - 65 years
Gender: All

(1) DSM-5 diagnosis of bipolar disorder;

(2) current depression: current Montgomery-Asperg Depression Rating Scale (MADRS)48 ³ 20,

(3) all genders,

(4) age 22-65 (age 22 chosen to increase validity of BD diagnosis);

(5) able to provide informed consent and provide verifiable contact information;

(6) stable medication regimen, must include a mood stabilizer.

Updated on 28 Oct 2025. Study ID: 23-1831

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