Delphi-MD TMS EEG TBI Study

To assess TMS-EEG abilities to aid in diagnosis, prognosis, and classification of TBI patients and predictions of clinical outcomes as well as to assess Delphi-MD abilities in the classification of TBI injury in comparison to standard brain measures. Differentiating between healthy controls and TBI participants in measured outputs of the Delphi-MD device (WFA, STP, EPD, LPD, and connectivity) Correlating Delphi-MD outputs with neural deficits identified through patient reported and clinician reported outcome measures. The following functional outcome and symptom measures will be obtained as primary outcomes in all groups: Glasgow Outcomes Scale-Extended (GOSE), Brief Symptom Inventory-18 (BSI-18), Rivermead Post-Concussion Symptom Questionnare (RPQ), Satisfaction with Life Scale (SWLS). TMS-EEG outputs will differ between TBI subjects with high symptom burden and those with low symptom burden (defined by RPQ and BSI-18). TMS-EEG outputs will correlate with MRI measures of axonal integrity (White matter fractional anisotrophy (FA) on DTI-MRI). While MRI is not a requirement for this study, we expect that a substantial subset of participants in this study will be co-enrolled in other MRI studies at out center.

You may be eligible for this study if you meet the following criteria:

• Conditions:
  Medical Research
• Age: - 99 Years
• Gender: All