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Intraoperative Electrophysiological Recordings and Non-Invasive Wearable Sensors for Movement Capture During Awake Brain Surgery
Recruiting
18-75 years
All
Phase
N/A
75 participants needed
1 Location
Brief description of study
Objective:
- To conduct electrophysiological experiments in human patients undergoing awake brain surgery with the aim of elucidating how the various brain regions coordinate their activity during naturalistic movements.
- Evaluate the effectiveness of various electrode arrays for recording of cortical activity.
- How the brain coordinates body movements and processes sensations such as touch.
- How the brain helps coordinate different functions such as the movement of your body or learning a particular movement sequence.
- Evaluate how electrophysiological signals in the sensorimotor cortex and subcortex are related to natural behaviors or stimuli.
Overview:
Asked to allow us to place an electrode array on the surface of your brain. The total amount of time for participation in study tasks is estimated to be approximately 45-50 minutes on average. This includes performances of tasks by the subject for 15-20 minutes plus additional time for setup and conclusion (30 minutes). During these tasks, we will record signals from your brain and may ask you to perform some simple movement, language, or perception tasks. We may deliver electrical stimulation to the surface of the brain to elicit sensations through the same electrodes being used for recording. We would also place a special set of wearable (non-invasive) sensors on your body to capture your body movement information without the need for special cameras. Your movements may also be captured (no facial visibility) with a standard video camera to better understand how the wearable sensors capture your movements. Any video data would only be used for comparison with the movement sensors information.
Detailed description of study
During the research recordings we may ask you to perform one of several simple tasks which could include:
1) Reaching to an object and grasping/releasing it
We could move the object in front of you and ask you to continue to reach to the object and release it for several minutes.
2) Mimic hand gestures or movements shown on a computer monitor
You may be asked to simply mimic the gestures or movements shown or you may be asked to memorize a sequence and continue to perform it.
3) Viewing of images or movies displayed on a computer monitor or other display
We could then ask you to describe what you saw on the display, or to answer simple questions about it.
4) Listening to audio recordings
We could then ask you to describe or repeat what you heard, or to answer simple questions about what you heard.
5) Responding to tactile sensations
We may ask you to describe the sensations you perceive when various stimuli such a light pressure or buzzing sensation are applied to your upper extremity (arms and hands) or lower extremities (legs and feet).
6) We may ask you to describe the sensations you perceive while stimulating the surface of the brain. You may be asked to qualitatively describe these sensations.
Eligibility of study
You may be eligible for this study if you meet the following criteria:
- Conditions: Medical Research
-
Age: Between 18 Years - 75 Years
-
Gender: All
Inclusion Criteria:
1.
Patients expected
to undergo awake craniotomy or burr hole procedure that will expose the
cerebral cortex, including deep brain stimulation surgery and supratentorial
craniotomy for tumor, epilepsy, or cerebrovascular disorders.
2.
Patients
between the ages of 18 and 75 years,
3.
Cortical
Stimulation: Patients undergoing a craniotomy where cortical stimulation is
utilized for their clinical procedure or patients undergoing deep brain
stimulation surgery with no prior history of seizures.
Exclusion Criteria:
1.
Patients
unwilling or unable to provide informed consent.
2.
Patients
with major medical co-morbidities and other surgical contra-indications such as
coagulopathy, as defined by past medical history and abnormal lab work at
the principal investigator’s discretion.
3.
Patients
with tumors with evidence of prior hemorrhage.
4.
Patients
with history of hemorrhagic strokes near the area of surgery.
5. Patients undergoing emergent neurosurgical treatment with acute or
worsening neurological deficits.
Updated on
01 Aug 2024.
Study ID: 852828
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