UPCC 12824 Risk Reducing Salpingectomy with Delayed Oophorectomy

Recruiting

99 years or below

Female

Phase N/A

1 Location

Brief description of study

The purpose of the study is to compare risk reducing salpingectomy with delayed oophorectomy to risk-reducing salpingo-oophorectomy in high risk-women.

Detailed description of study

To enroll, patients must meet eligibility criteria and sign ICF (no additional testing needed). After enrolling, patients fill out demographic and family history questionnaires. After surgery (RRSO or RRS/RRO), patients will have yearly follow-ups so the study team can collect information about the patient's health status.

Eligibility of study

You may be eligible for this study if you meet the following criteria:

Conditions: Ovarian cancer prevention. BRCA1, BRCA2, BRIP1, RAD51C, RAD51D
Age: 99 years or below
Gender: Female

Inclusion

1. Premenopausal women with a documented deleterious mutation in BRCA1, BRCA2, BRIP1, RAD51C and/or RAD51D gene germline mutation

2. Age 25-40 years for BRCA1 mutation carriers, 25-45 years for BRCA2 and 30-50 years for BRIP1, RAD51C, RAD51D

3. Childbearing completed or no longer requires fallopian tubes

4. Presence of at least one fallopian tube

5. Participants may have a personal history of non-ovarian malignancy

6. Informed consent must be obtained and documented

Exclusion

1. Post menopausal status (natural menopause or due to (cancer) treatment)

2. Wish for second stage RRO within two years after RRS (if clear at enrollment)

3. Legally incapable

4. Prior bilateral salpingectomy

5. A personal history of ovarian, fallopian tube or peritoneal cancer

6. Current clinical signs, diagnosis or treatment for malignant disease

Updated on 08 Oct 2025. Study ID: 24-0665

Find a site

Your Information has been sent successfully.

We have submitted the contact information you provided to the research team at {{SITE_NAME}}. A copy of the message has been sent to your email for your records.

Would you like to be notified about other trials? Sign up for Patient Notification Services.

Send a message

Enter your contact details to connect with study team

View email

Phone

View phone

First name*

Last name*

Email*

Phone number*

Preferred way of contact

Please provide your preferred way of contact

Other language

By Submitting your information, you agree that your details may be shared with the selected study site and handled in accordance with this Website's Privacy Policy (see link in footer). You may be contacted by email, text message, or phone regarding this study and other research opportunities that may be of interested to you. You can unsubscribe from these communications at any time. Message and data rates may apply.

Interested in the study

Select a study center that’s convenient for you, and get in touch with the study team.