URBI Study

Primary Objective: Determine if high definition white light colonoscopy (HDWLC) using a limited biopsy strategy is non-inferior to HDWLC using a random biopsy strategy to detect dysplasia or sessile serrated adenoma (SSA) in patients with IBD. Secondary objectives:

1.      Determine if HDWLC using a limited biopsy strategy is superior to HDWLC with a random biopsy strategy to detect one or more dysplastic or SSA lesion in patients with IBD
2.      Determine whether the number of targeted biopsies differs based on the number of random biopsies obtained. 
3.      Define the molecular characteristics of the progression of colitis-associated dysplasia Average number of dysplastic or SSA lesions detected per colonoscopy

The number of dysplastic or SSA lesions will be defined as the number of pathology jars containing a specimen with low-grade or high-grade dysplasia (including CRC) or serrated changes consistent with a sessile serrated adenoma-like change. Even if there are more than one biopsy sample in a jar with dysplasia or SSA, it will be counted as one location with dysplasia or SSA. For each colonoscopy, the number of pathology jars with dysplastic or SSA lesions will be tabulated as 0, 1, 2, etc. Proportion of patients with one or more dysplastic or SSA lesion.

You may be eligible for this study if you meet the following criteria:

• Conditions:
  Medical Research
• Age: - 99 Years
• Gender: All