Uterine Preservation in the Management of Placenta Accreta Spectrum Disorders (U-PRESERVE)
Recruiting
18 years - 99 years
Female
Phase
N/A
15 participants needed
1 Location
Brief description of study
The protocol is for the conservative management
of placenta accreta spectrum disorders (PAS), which are a major cause of
maternal morbidity and mortality. The most common management strategy for PAS
in the United States is a preterm cesarean-hysterectomy. However, accumulating
data show that conservative management is safer and is preferred by some
patients. In selected patients who desire uterine preservation, we provide
the option of conservative management, which will be defined as leaving the
placenta in the uterus after delivery of the infant.
Eligibility of study
You may be eligible for this study if you meet the following criteria:
- Conditions: Medical Research
-
Age: 18 years - 99 years
-
Gender: Female
To be eligible to participate in this
study, an individual must meet all of the following criteria:
1.
Provision of signed
and dated informed consent form.
2.
Stated willingness to
comply with all study procedures and availability for the duration of the study.
3.
A person with a
uterus, age 18 or older
4.
Currently 16-36 weeks
pregnant with an intrauterine gestation
5. History
of cesarean delivery AND placenta previa OR anterior low-lying placenta AND
suspected of having PAS on prenatal imaging (ultrasound/MRI)
6. Patients
for whom the usual management would be cesarean-hysterectomy.
7. Patient
desires uterine preservation
8.
Agreement to adhere
to Lifestyle Considerations throughout study duration.
Updated on
30 Mar 2026.
Study ID: 23-1740
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