Physiology of the Weight Reduced State | Clinical Research Studies Listing

Recruiting

25 years - 60 years

All

102 participants needed

1 Location

Brief description of study

POWERS (Physiology of the Weight Reduced State) is a national research study funded by the NIH. The study involves a behavioral weight loss intervention, a weight-stable period, and an observational phase. Participants will monitor their weight at home with an internet-connected scale and come to Penn Medicine for two screening visits and four assessment periods involving physical and behavioral testing.

Detailed description of study

What does the study involve?

Phase 1:

Screening and informed consent including some medical measures
Outpatient and overnight hospital visits where you will complete physiological and behavioral tests
20-week behavioral weight loss intervention with a target to lose at least 7% of your current weight
Weekly meetings, daily food logs and activity measurement, meal replacements

Weight stabilization:

Once weight loss ends, you will remain at your reduced weight for two weeks prior to your second assessment period
You will again complete outpatient and overnight hospital visits with physiological and behavioral tests

Phase 2: 12 Months of Weight Maintenance

Behavioral weight loss intervention ends. Weekly weight and activity monitoring and monthly food recalls are done at home or over Zoom.
Two more assessment periods with outpatient and overnight hospital visits at months 4 and 12 with physiological and behavioral tests

Interested? Go to https://www.powers-study.org/

Eligibility of study

You may be eligible for this study if you meet the following criteria:

Conditions: Medical Research, weight loss, weight regain, obesity
Age: 25 years - 60 years
Gender: All

You are eligible if you:

Are between the ages of 25-60
Do not have Type 1 or Type 2 diabetes
Have a BMI between 30- <40 kg/m2
Calculator: https://www.nhlbi.nih.gov/health/educational/lose_wt/BMI/bmicalc.htm
Would like the opportunity to participate in a weight loss intervention study

Updated on 06 Jul 2026. Study ID: 22-1612

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