Pilot Study of a Multi-System Analysis of Opioid Receptor Binding
Not Recruiting
18 years - 50 years
All
Phase
N/A
60 participants needed
1 Location
Brief description of study
The
purpose of this research is to learn more about mu opioid receptor (MOR)
binding in the brain and body.
This study will enroll up to 60 adults in three cohorts of up to 20 participants each:
- Cohort 1: Subjects with a lifetime diagnosis of Opioid Use
Disorder (OUD) on a stable dosage of buprenorphine or methadone for medication-assisted
treatment (MAT) for at least four weeks prior to the screening visit
-
Cohort 2:
Subjects with a lifetime history of OUD, but not current OUD who have not received MAT for OUD
during the 12 months prior to screening
-
Cohort
3: Subjects without a lifetime history
of OUD
In this study, we examine the distribution of a kind of receptor that binds
opioids (opioids are chemicals that are either produced normally by the body or
taken as medications, like morphine or codeine, which are prescribed by doctors
to reduce pain). These opioid receptors, which are widely distributed in the
brain and other organs, such as the intestines, are involved in the experience
of reward, and they play a role in reducing pain. We will study this
using a type of Positron Emission Tomography (PET/CT) scan using a radioactive
imaging drug called [11C]carfentanil that binds to this type of
receptor.
[11C]carfentanil
is an experimental radioactive imaging
drug used in PET imaging to measure mu-opioid
receptors (MORs) in various organs in the body, including the brain. [11C]carfentanil has not yet been
approved by the Food and Drug Administration (FDA) for use except in a research
study. The use of [[11C]carfentanil in this study is allowed under
an Investigational New Drug Application approved by the FDA.
Eligibility of study
You may be eligible for this study if you meet the following criteria:
- Conditions: Healthy Controls,Opioid Use Disorder,History of Opioid Use Disorder,Opiate use,Opioid Use
-
Age: 18 years - 50 years
-
Gender: All
Updated on
11 Sep 2024.
Study ID: 851051
