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Functional and Structural Assessment of Endobronchial Valve Recipients Using Dynamic Hyperpolarized Xenon-129 MRI
Recruiting
18 years and older
All
Phase
N/A
100 participants needed
1 Location
Brief description of study
The research study is being conducted to determine the effectiveness of using hyperpolarized xenon-129 magnetic resonance imaging (MRI) in diagnosing and predicting treatment outcomes for patients who received endobronchial valve (EBV) therapy to treat chronic obstructive pulmonary disease (COPD). COPD is a disease of the lungs caused most often by smoking. Bronchoscopic lung volume reduction (BLVR), is an FDA-approved treatment for select patients with severe COPD.
Detailed description of study
Participants will be asked to complete the following research procedures:
• Quality of Life Pulmonary Questionnaires:
o St. Georges Respiratory Questionnaire
o Modified Medical Research Council Questionnaire
o COPD Assessment Test (CAT)
• Pulmonary function test (if not completed with your physician prior to attending the study)
• Practice for the breathing procedure being performed during the study
• MRI scanning using the inhaled MRI contrast agent Hyperpolarized Xenon-129 (HP 129Xe)
Eligibility of study
You may be eligible for this study if you meet the following criteria:
- Conditions: Chronic obstructive pulmonary disease, COPD
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Age: 18 Years
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Gender: All
Patients with COPD and severe emphysema who are undergoing evaluation for lung volume reduction surgery or endobronchial valve placement,
-OR-
Healthy volunteers aged 40 years and older are also eligible for this study.
Updated on
13 Sep 2024.
Study ID: 851358
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