This study is currently not recruiting participants.

Responsive Neurostimulation for Loss of Control Over Eating

Responsive Neurostimulation for Loss of Control Over Eating
Not Recruiting
22 years - 70 years
All
Phase N/A
4 participants needed
1 Location

Brief description of study

This is an early feasibility study looking at the safety, feasibility, and potential benefit of a medical device, called the NeuroPace RNS System, for people suffering from obesity, with uncontrolled eating habits.

Detailed description of study

A small number of people report feeling distressed about their inability to control their eating. They eat certain foods even when not physically hungry or do not stop their eating despite being full. Sometimes current treatments such as behavioral (talk) therapies, medication, and bariatric surgery may not help. Penn's Metabolic and Bariatric Surgery Program is partnering with Dr. Casey Halpern's team in the Department of Neurosurgery to consider additional options for people with loss-of-control eating who have not improved with conventional treatments.

Eligibility of study

You may be eligible for this study if you meet the following criteria:

  • Conditions: Weight Loss,Obesity
  • Age: 22 years - 70 years
  • Gender: All

You may be eligible to participate in an FDA-approved research study if you meet the following criteria:

You are between 22 and 70 years old.
You have a Body Mass Index (BMI) of 35 to 60 kg/m².
You have undergone either gastric bypass or gastric sleeve surgery.
You have previously tried FDA-approved weight loss medications and behavioral therapies without success.

If you meet these criteria, a staff member would be happy to discuss the research project titled "Responsive Neurostimulation of Loss of Control Overeating" with you.

Updated on 10 Sep 2025. Study ID: 21-1545

Interested in the study

Select a study center that’s convenient for you, and get in touch with the study team.

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