Noninvasive Quantification of Renal Oxygen Utilization in Early Kidney Disease

Type 2 diabetes is the most common cause of chronic kidney disease (CKD). In people with diabetes, the kidneys do not function normally and continuously require more oxygen to remove waste from the body. This process, in-turn, depletes the available supply of oxygen, causes damage to the tissue itself, and may eventually lead to CKD. This increase in kidney oxygen consumption often goes undetected until permanent damage has already occurred. This study will test the sensitivity of a new technique in measuring oxygen consumption by the kidneys in people with early diabetic kidney disease. This will be done with a new magnetic resonance imaging (MRI) method that measures the oxygen content of blood in the renal vein, which drains blood away from the kidneys. MRI is an examination that uses magnetic fields and radio waves to produce pictures of the inside of the body. This study will help us better understand how the kidneys use oxygen during the early stages of CKD and may help lead to earlier and more accurate detection when the disease state is still reversible.

You may be eligible for this study if you meet the following criteria:

• Conditions: Pre-Diabetes, Diabetes
• Age: 18 years - 59 years
• Gender: All