TACE Ax HCQ: Phase IB Study of Hepatic Chemoembolization Plus Axitinib and Hydrochlorquine for Liver-Dominant Metastatic Adenocarcinoma Of The Colon And Rectum
Recruiting
18-99 years
All
Phase
1
10 participants needed
1 Location
Brief description of study
Liver metastases are a leading cause of death among patients with metastatic colorectal cancer. Duration of disease control is short following 2nd-line or later systemic therapy. Liver-directed therapy such as TACE has a higher response rate and improves PFS, but the benefit is still limited. Cancer cells escape ischemic cell death via autophagy and HIF activation. We hypothesize that blocking autophagy and the VEGF pathway will improve both response and PFS following TACE.
The target population are those patients with liver-only or liver-dominant metastatic colorectal cancer failing at least one line of systemic chemotherapy due to progression or toxicity.
Subjects will be recruited from the Gastrointestinal and Interventional Oncology Clinics at the University of Pennsylvania Abramson Cancer Center
Eligibility of study
You may be eligible for this study if you meet the following criteria:
- Conditions: Metastatic Adenocarcinoma,colon,rectum,cancer
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Age: Between 18 Years - 99 Years
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Gender: All
Updated on
01 Aug 2024.
Study ID: 848444
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