Cystic Fibrosis Microbiome
Enrolling By Invitation
18-99 years
All
Phase
N/A
24 participants needed
1 Location
Brief description of study
Among lung transplant recipients who survive to 5 years, half suffer from chronic lung allograft dysfunction (CLAD). This study will evaluate how changes in the lung microbiome may cause CLAD in Cystic Fibrosis patients who have been transplanted.
This is a case-control study of Cystic Fibrosis lung transplant recipients to define the lower respiratory tract microbiome at the time of incident CLAD and determine the relationship between allograft microbiome, host response, and CLAD.
Patients with clinical CLAD who are scheduled to undergo clinical bronchoscopy will be recruited for this study alongside matched control subjects that will undergo research bronchoscopy for sample collection.
Subjects will be recruited from
established patients within the University of Pennsylvania, Johns
Hopkins University, and University of Pittsburgh Lung Transplant
Programs.
Eligibility of study
You may be eligible for this study if you meet the following criteria:
- Conditions: cystic fibrosis
-
Age: Between 18 Years - 99 Years
-
Gender: All
Updated on
01 Aug 2024.
Study ID: 834250
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