Assessment of Chronic Lung Allograft Dysfunction Using Single-Breath & Multi-Breath Hyperpolarized Xenon 129 MRI
Recruiting
18-90 years
All
Phase
N/A
60 participants needed
1 Location
Brief description of study
We are investigating if using a special type of non-radiation
imaging (inhaled hyperpolarized xenon with MRI) in lung transplant recipients can
outperform current standard tests for transplant rejection. Presently, clinical
assessments such as pulmonary function testing (PFT) are able to detect
rejection of the transplanted lungs, however, they can only do so much once the
process of transplant rejection has already begun. The purpose of this study is
to determine if hyperpolarized xenon is capable of outperforming PFTs in
detecting alterations in lung functionality following transplant.
Detailed description of study
If you agree to join the study, you will be asked to complete the following research
procedures:
• Complete a brief MRI safety questionnaire
• Practice the breathing procedure that will be performed during the study
• MRI scanning using the inhaled MRI contrast agent Hyperpolarized Xenon129 (HP 129Xe)
Your participation will last for up to two years with up to 5 follow-up visits.
Eligibility of study
You may be eligible for this study if you meet the following criteria:
- Conditions: pulmonary, lung transplant
-
Age: Between 18 Years - 90 Years
-
Gender: All
Patients who have received a lung transplant within the past 3 months, or are scheduled to receive a transplanted lung.
Updated on
09 Sep 2024.
Study ID: 834759
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