UPCC 25118 Pilot Study Evaluating the Uptake of [18F]F-Gln by PET/CT in Breast Cancer ([18F]F-GLN)
Investigating PET/CT Imaging in Breast Cancer
Brief description of study
Patients with known or suspected primary or metastatic breast cancer with one lesion that is 1.0 cm in diameter or greater may be eligible for this study. Patients may participate in this study if they are at least 18 years of age. Up to 40 evaluable subjects will participate in a single imaging cohort. Patients will be stratified for analysis by breast cancer subtype with prioritization to recruit at least 10 estrogen-receptor-expressing (ER+) and 10 triple-negative breast cancers (TNBC). Participants may be treatment naïve or have received up to 3 weeks of treatment at the time of the [18F]F-Gln PET/CT scan.
This is an observational study; [18F]F-GLN PET/CT will not be used to direct treatment decisions. While patients and referring physicians will not be blinded to the [18F]F-GLN PET/CT results, treatment decisions are made by the treating physicians based upon clinical criteria.
[18F]F-GLN PET/CT imaging sessions will include an injection of [18F]F-GLN. Metabolism data will be collected. Pilot data will be collected to evaluate image quality and collect preliminary information on the uptake of [18F]F-GLN in breast cancer. Uptake measures will be compared to tumor markers of glutamine metabolism, when tissue is available. The safety of [18F]F-GLN will also be evaluated in all subjects.
Detailed description of study
Up to 40 patients will undergo approximately 60 minutes of dynamic PET scanning followed by up to 2 static skull-base to mid-thigh scans post injection of [18F] (2S,4R)4-fluoroglutamine ([18F]F-GLN). A baseline FDG-PET/CT will also be performed, either as a routine clinical staging/re-staging scan or as a research scan. If performed as a research scan, the scan may include an optional dynamic imaging session. Some subjects, who undergo systemic therapy as part of their clinical treatment, may also undergo an optional second [18F]F-GLN PET/CT to collect pilot data on the changes in [18F]F-GLN uptake in response to therapy. Subjects who undergo a second [18F]F-GLN PET/CT may have a second FDG-PET/CT, again either as a standard-of-care restaging study or as an optional research scan. The timing of the optional second PET scans will vary depending on the type of treatment the subject is receiving. If the subject moves during their scans, a low-dose CT attenuation may be repeated following the dynamic scan at the PI's discretion.
Eligibility of study
You may be eligible for this study if you meet the following criteria:
- Conditions: Breast Cancer
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Age: 18 years or above
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Gender: All
Inclusion Criteria:
- Participants will be ≥ 18 years of age
- Known or suspected primary or metastatic breast cancer.
- At least one lesion ≥ 1.0 cm that is seen on standard imaging (e.g. CT, MRI, mammogram, ultrasound, FDG-PET/CT). Only one type of imaging is required to show a lesion.
- Participants must be informed of the investigational nature of this study and be willing to provide written informed consent and participate in this study in accordance with institutional and federal guidelines prior to study-specific procedures.
Exclusion Criteria:
- Females who are pregnant or breast feeding at the time of screening; a urine pregnancy test will be performed in women of child-bearing potential at screening.
- Inability to tolerate imaging procedures in the opinion of an investigator or treating physician.
- Any current medical condition, illness, or disorder, as assessed by medical record review and/or self-reported, that is considered by a physician investigator to be a condition that could compromise participant safety or successful participation in the study.
This study investigates the use of PET/CT imaging to evaluate the uptake of a special substance called [18F]F-Gln in patients with breast cancer. This study includes patients with known or suspected primary or metastatic breast cancer, which means the cancer may have spread to other parts of the body. The study focuses on understanding how this imaging technique can show the presence of cancerous lesions, which are abnormal areas of tissue that might be cancerous.
Participants will undergo a PET/CT imaging session, which involves an injection of [18F]F-Gln. This imaging helps to collect data on how the substance is taken up by cancer cells. The study will also evaluate the safety of [18F]F-Gln. In some cases, a second PET/CT scan might be done to see how the uptake changes after treatment. The imaging sessions will last about 60 minutes, and data will be compared to tumor markers when available.
- Who can participate: Participants must be 18 years or older with known or suspected breast cancer and at least one lesion 1.0 cm or larger visible on imaging. They must be able to provide informed consent and not be pregnant or breastfeeding.
- Study details: Participants will receive an injection of the investigational substance for PET/CT imaging to assess cancer activity. Some may have a second scan to observe changes after treatment. This study does not influence treatment decisions.
Study is selecting its participants from a population, or group of people, decided on by the researchers in advance.
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