BLOCKade of Calcium Channels and Beta Adrenergic Receptors for the Treatment of Hypertension in Heart Failure with Preserved Ejection Fraction

Recruiting

18-99 years

All

Phase 1

50 participants needed

1 Location

Brief description of study

The purpose of the study is to compare how amlodipine versus metoprolol effect blood pressure in people with HFpEF.

While hypertension is the most common risk factor for HFpEF, there is little evidence on the potential role of common antihypertensive medications, specifically calcium channel blockers (like amlodipine) and β-blockers (like metoprolol), in the management of hypertension in HFpEF. The goal of this study is to better understand the mechanistic effects of these two antihypertensive medications in people with HFpEF so that we can potentially use these medications in the future to improve long-term blood pressure management, heart function, and symptom management.

Detailed description of study

The research study is being conducted to evaluate if different types of commonly used blood pressure medications (amlodipine and metoprolol) have different effects on blood pressure, exercise capacity, quality of life, and heart function in individuals with heart failure with preserved ejection fraction (HFpEF).

If you agree to join the study, you will be asked to complete the following research procedures:

· Three to four study visits, including physical exams, blood draws, questionnaires, echocardiograms, arterial tonometry, and exercise testing

· Taking the study medications at home for approximately four weeks each

· Self blood pressure monitoring at home

Your participation will last for approximately three months.

Eligibility of study

You may be eligible for this study if you meet the following criteria:

Conditions:
heart failure,hypertension,HFpEF
Age: Between 18 Years - 99 Years
Gender: All

Updated on 01 Aug 2024. Study ID: 833517

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