Found 12 Eye Disease trials
A listing of Eye Disease medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.
LCAT Deficiency Disorders: natural history and identification of biomarkers
Familial lecithin:cholesterol acyl transferase (LCAT) deficiency (FLD) is a rare, hereditary disease with no treatment. It is caused by mutations in the gene for LCAT, an enzyme that is made in the liver and plays a role in the body’s ability to process (“metabolize”) cholesterol. People with FLD have very …
Impact of Nicotine Messaging on Beliefs and Behavior
The purpose of this study is to examine the impact of nicotine messaging on beliefs and behavior while using investigational cigarettes with either normal nicotine levels or reduced nicotine levels.
Observational Characterization of the Treatment Course of Patients With Thyroid Eye Disease
This study will: • Evaluate standard-of-care (SOC) treatment for TED in a real-world setting • Evaluate effectiveness of the treatment in terms of protrusion of the eyeball (proptosis) • Show if the SOC treatment has any effect on eye anatomy and function and fi the appearance of the subject’s eyes …
Neurosensory Abnormalities in SymptomAtic Ocular Surface Patients
Primary Objectives: 1. To establish the prevalence of neuropathic corneal pain in patients with ocular surface discomfort. 2. To assess the overlap of neuropathic corneal pain with dry eye disease in patients in diseases that are currently thought to be mutually exclusive. 3. To establish the prevalence of subtypes of …
Safety and Tolerability of Subretinal OPGx-001 for LCA5-Associated Inherited Retinal Degeneration (LCA5-IRD)
To evaluate the safety and tolerability of OPGx-001 administered via subretinal injection to one eye (treated eye) of participants with LCA5-IRD. The safety and tolerability as assessed by: 1. Number of dose limiting toxicity (DLT) events at the proposed doses 2. Number of procedure-related adverse events (AEs) 3. Number and …
Zoster Eye Disease Study (ZEDS): A multi-center randomized double-masked placebo-controlled study of valacyclovir in immunocompetent subjects with a history of dendriform epithelial keratitis stromal keratitis endothelial keratitis and/or iritis due to Herpes Zoster Ophthalmicus (HZO) within the year prior to enrollment.
Phase 3
Request to rely on the lead site IRB, see attached documents
Assessment of T4032 (unpreserved bimatoprost 0.01%) versus Lumigan 0.01% in ocular hypertensive or glaucomatous patients
The purpose of this study is to find out about the safety and efficacy of T4032, which is a preservative-free formulation of bimatoprost (0.01%) for the treatment of glaucoma or ocular (eye) hypertension. There will be 5 to 6 study visits and participation will last up to 12 weeks (120 …
REDUCO
To evaluate the efficacy of 5 mcg/mL and 10 mcg/mL concentrations of the new formulation of rhNGF ophthalmic solution versus vehicle, in order to demonstrate superiority of at least one of the concentrations over vehicle in the improvement of ocular symptoms of dry eye in patients with dry eye disease …
GP44729
The purpose of this study is to assess the efficacy, safety, pharmacokinetics, and pharmacodynamics of subcutaneous satralizumab, a recombinant, humanized antiinterleukin-6 (IL-6) receptor monoclonal antibody, in participants with moderate-to-severe thyroid eye disease (TED).
DRCR AO
Patients with nAMD most commonly receive an anti-VEGF injection into the eye. A "Treat and Extend" method is used to determine how often injections are needed. OCT scans of the eye are used to determine when to give treatment. This study seeks to see how using a Home OCT device …
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