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Found 22 Acute Myeloid Leukemia trials
A listing of Acute Myeloid Leukemia medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.
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This study investigates the use of an investigational medication in combination with standard therapies for patients with acute myeloid leukemia (AML) who have specific genetic mutations and have not yet received treatment. The purpose of this study is to assess the benefits and risks of adding the investigational medication to …
This study investigates a treatment for adults with acute myeloid leukemia (AML) that has not responded to previous treatment or has returned after treatment. The purpose of this research is to evaluate the effectiveness and safety of an investigational medication given with Cytarabine, compared to a placebo given with Cytarabine. …
This study investigates the effects of a combination of investigational medications in patients newly diagnosed with secondary acute myeloid leukemia (AML) after previous exposure to hypomethylating agents. The purpose of this study is to understand how these investigational medications work together to treat AML.Participants in the study will receive a …
This study investigates a potential treatment for Acute Myeloid Leukemia (AML). The purpose of this study is to explore the use of a modified stem cell transplant combined with engineered T cells, known as chimeric antigen receptor (CAR) T cells, to target and attack leukemia cells. CAR T cells are …
Determine if RAS Inhibitors inhibit the in vitro growth of RAS mutant primary human AML cells. This is a pre-clinical evaluation. There is only one outcome to be measured. The assay is a colony forming assay. AML cells form colonies which are manually counted. Endpoint will be a statistically significant …
This study investigates the impact of assessing physiologic age in patients newly diagnosed with acute myeloid leukemia (AML) who are 50 years or older. The purpose is to understand how evaluating patients' overall health rather than just their chronological age can affect treatment outcomes such as toxicity, early mortality, remission …
This study investigates the safety and feasibility of using T-cell receptor engineered donor T-cells in patients undergoing allogeneic peripheral blood stem cell transplantation. The study focuses on patients with acute myeloid leukemia (AML), myelodysplastic syndromes (MDS), or acute lymphoblastic leukemia (ALL) who receive transplants from specific types of donors. The …
This study investigates the safety and effectiveness of an investigational medication in patients with relapsed or refractory leukemias, including those with specific genetic changes such as MLL/KMT2A gene rearrangement or NPM1 mutation. The study is divided into two phases: Phase 1 aims to find the best dose of the investigational …
This study investigates the use of unlicensed cryopreserved cord blood units (CBUs) for transplantation in pediatric and adult patients with hematologic malignancies and other conditions. The purpose of this study is to understand how well patients recover neutrophil levels, a type of white blood cell important for fighting infections, after …
This study investigates how effective one year versus two years of maintenance therapy is for patients with advanced ovarian cancer that has BRCA1/2 mutations or is homologous recombination deficient (HRD+). The purpose is to compare the effects of using the investigational medication, olaparib, with or without an antiangiogenic agent, bevacizumab, …
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