Found 10 Glioblastoma multiforme trials
A listing of Glioblastoma multiforme medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.
Glioblastoma adaptive global innovative learning environment
Phase 2
This research study aims to evaluate multiple investigational treatments for either newly diagnosed or recurrent brain tumors to determine if any of these study treatment(s) improve overall survival as compared to standard treatments. The investigational drugs that will be used in this research study are temozolomide for newly diagnosed glioblastoma …
ImmuneSense Study- Safety and Efficacy of IGV-001 an Autologus Cell Immunotherapy With Antisense Oligonucleotide (IMV-001) Targeting IGF-1R in Newly Diagnosed Patients With Glioblastoma Multiforme
Phase 2
The purpose of this study is to see how safe the study medicine, IGV-001 plus standard of care (SOC), is and to compare IGV-001 with placebo (only standard of care) to see if it works in slowing GBM tumor regrowth. Participants for this study will be recruited from the patient …
Evaluating CART-EGFR-IL13Ra2 Cells Following Lymphodepleting Chemotherapy in Patients With EGFR-Amplified Recurrent Glioblastoma
Phase 1
This research study is being conducted to evaluate an experimental drug called CART EGFR-IL13Ra2 cells in patients with glioblastoma that has returned or worsened on current treatment.
Study of Enzastaurin Added to Temozolomide During and Following Radiation Therapy in Newly Diagnosed Glioblastoma Patients
Phase 3
The research study is being conducted to investigate the potential benefits of Enzastaurin in combination with temozolomide and radiation therapy in newly-diagnosed glioblastoma patients with the Denovo Genomic Marker1 (DGM1).
Investigating Potential of Personalized Biomarkers in Redefining Treatment Response in Patients with Glioblastoma using Multiparametric MRI and Liquid Biopsy
This study aims to investigate 30 patients with a diagnosis of Glioblastoma to develop a decision support system by incorporating advanced MR imaging, liquid biopsy, and MGMT promoter status to determine with higher accuracy whether tumor changes are true progression or pseudo progression. Analysis of these results will hopefully have …
Whole-Brain Spectroscopy Guided Personalized Delivery of Tumor Treating Fields in Glioblastoma Patients
The research study is for Glioblastoma (GBM) patients beginning Optune, a therapy that uses - tumor treating fields (TTFields). As a part of this study participants will either receive Optune with standard treatment array mapping from MR imaging or an alternative treatment array mapping based on advanced MR imaging also …
Detection of cell-free circulating tumor DNA in patients with glioblastma undergoing treatment with first-line chemoradiotherapy
Glioblastoma (GBM) is the most common primary brain tumor in adults and is uniformly fatal. During standard adjuvant treatment for GBM following initial surgical resection of the tumor, patients are treated with a combination of radiation and chemotherapy. During and after this adjuvant treatment, patients are monitored for disease progression …
NRG-BN010
The primary hypothesis of this study is that the combination of tocilizumab, atezolizumab , and FSRT will lead to a robust anti-tumor immune response in GBM. This hypothesis is based on strong preclinical data, which has demonstrated (1) critical roles for IL-6 in GBM immune evasion, (2) that targeting IL-6 …
Insightec - BT015
The purpose of this prospective, self-controlled study is to evaluate the safety and effectiveness of using Exablate Model 4000 Type-2.0/2.1 in adults with Glioblastoma brain tumors to increase temporarily the permeability of the blood brain barrier, allowing increased passage of circulating free DNA (cfDNA) for sampling and analysis.
Circulating Biomarkers for Glioma
Subjects will be recruited from the Radiation Oncology and Neurosurgery practices at the Hospital of the University of Pennsylvania. The treating radiation oncologist will determine if the patient is a potential research candidate and has the capacity to consent. The goal of this study is to collect and analyze blood …
