Found 16 Neoplasms trials
A listing of Neoplasms medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.
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This study investigates the effects of an investigational medication compared to a placebo in participants with myocarditis linked to immune checkpoint inhibitors (ICI). This condition can occur as a side effect of cancer treatments that use ICIs to enhance the body's immune response against cancer cells. The purpose of this …
This study investigates the effectiveness of an investigational medication compared to observation in treating intermediate risk non-muscle invasive bladder cancer (IR-NMIBC). The purpose of this study is to see if the investigational medication can help prevent the cancer from returning after the initial surgical removal of the tumor.Participants in the …
This study investigates different methods for monitoring pancreatic cysts. Monitoring these cysts is important to prevent complications. The purpose of this study is to compare two approaches: more frequent monitoring versus less frequent monitoring, to see which one leads to better outcomes for patients with pancreatic cysts.Participants in the study …
This study investigates the use of an investigational medication, a monoclonal antibody targeting Tumor Necrosis Factor Receptor 2 (TNFR2), in people with advanced malignancies. The purpose of the study is to evaluate the safety and tolerability of the investigational medication both alone and in combination with pembrolizumab, a type of …
The purpose of this study is to investigate the effects of immune checkpoint inhibitors (ICI) on the heart and circulatory system in patients with breast cancer or non-small cell lung cancer. This study focuses on understanding how these medications, which are used in cancer treatment, might impact heart health. An …
This study investigates the safety and effectiveness of an investigational medication for individuals with CALR-mutated myeloproliferative neoplasms, which include conditions like essential thrombocythemia (ET) and myelofibrosis (MF). The purpose of this study is to find the best dose and schedule for the investigational medication.Participants will receive the investigational medication either …
This study investigates an investigational medication for patients with advanced non-small cell lung cancer (NSCLC) and other solid tumors that have a specific change in the anaplastic lymphoma kinase (ALK) gene. The purpose of this study is to find out how safe and tolerable the investigational medication is, and to …
This study investigates an investigational medication for adults with advanced MTAP-null solid tumors. The study aims to evaluate the safety and tolerability of the investigational medication alone and in combination with another treatment called docetaxel.Participants will receive the investigational medication orally, and their health will be monitored to assess the …
This study investigates the effectiveness of two surgical procedures in reducing the risk of ovarian cancer in individuals with BRCA1 mutations. The purpose of this study is to compare bilateral salpingectomy, which involves removing the fallopian tubes, with bilateral salpingo-oophorectomy, which involves removing both the fallopian tubes and ovaries. These …
The purpose of this study is to obtain consent to biobank skin specimens for future research studies. Skin growths, skin cancer, autoimmune or inflammatory skin diseases, and normal skin may be banked. Eligible patients include those who are seen at the University of Pennsylvania Health System clinical practices. For patients …
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