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Found 15 Neoplasms trials

A listing of Neoplasms medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

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99 years or below
All genders
The research study is being conducted to test the safety of ALN-6400 and find out what effects, if any, ALN-6400 has on people with Von Willebrand Disease (VWD) and Heavy Menstrual Bleeding (HMB).
UPCC 28922 AbatacepT foR ImmUne checkpoint inhibitor associated Myocarditis (ATRIUM): A Phase 3, Investigator-Initiated, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of Abatacept Compared to Placebo in Participants with Immune Checkpoint Inhibitor Associated Myocarditis
18 years or above
All genders
Phase 3
Interventional
This study investigates the effects of an investigational medication compared to a placebo in participants with myocarditis linked to immune checkpoint inhibitors (ICI). This condition can occur as a side effect of cancer treatments that use ICIs to enhance the body's immune response against cancer cells. The purpose of this …
18 years or above
All genders
Phase 3
Interventional
This study investigates the effectiveness of an investigational medication compared to observation in treating intermediate risk non-muscle invasive bladder cancer (IR-NMIBC). The purpose of this study is to see if the investigational medication can help prevent the cancer from returning after the initial surgical removal of the tumor.Participants in the …
50 years - 75 years
All genders
Observational
This study investigates different methods for monitoring pancreatic cysts. Monitoring these cysts is important to prevent complications. The purpose of this study is to compare two approaches: more frequent monitoring versus less frequent monitoring, to see which one leads to better outcomes for patients with pancreatic cysts.Participants in the study …
18 years or above
All genders
Phase 1/2
Interventional
This study investigates the use of an investigational medication, a monoclonal antibody targeting Tumor Necrosis Factor Receptor 2 (TNFR2), in people with advanced malignancies. The purpose of the study is to evaluate the safety and tolerability of the investigational medication both alone and in combination with pembrolizumab, a type of …
18 years or above
All genders
Phase 1
Interventional
This study investigates the safety and effectiveness of an investigational medication for individuals with CALR-mutated myeloproliferative neoplasms, which include conditions like essential thrombocythemia (ET) and myelofibrosis (MF). The purpose of this study is to find the best dose and schedule for the investigational medication.Participants will receive the investigational medication either …
12 years or above
All genders
Phase 1/2
Interventional
This study investigates an investigational medication for patients with advanced non-small cell lung cancer (NSCLC) and other solid tumors that have a specific change in the anaplastic lymphoma kinase (ALK) gene. The purpose of this study is to find out how safe and tolerable the investigational medication is, and to …
99 years or below
All genders
This is a multicenter, multi-arm, biomarker-stratified trial designed to evaluate biomarker-directed therapies in patients with estrogen receptor-positive/hormone receptor-negative (ER+/HR-) and triple-negative (TN) metastatic breast cancer (MBC). The trial integrates both retrospective and prospective data collection, including archival tumor tissue, medical record abstraction, and prospective tumor and blood sampling prior to …
18 years - 100 years
All genders
Phase 1/2
Interventional
This study investigates an investigational medication for adults with advanced MTAP-null solid tumors. The study aims to evaluate the safety and tolerability of the investigational medication alone and in combination with another treatment called docetaxel.Participants will receive the investigational medication orally, and their health will be monitored to assess the …
35 years - 50 years
Female
Interventional
This study investigates the effectiveness of two surgical procedures in reducing the risk of ovarian cancer in individuals with BRCA1 mutations. The purpose of this study is to compare bilateral salpingectomy, which involves removing the fallopian tubes, with bilateral salpingo-oophorectomy, which involves removing both the fallopian tubes and ovaries. These …
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