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Found 14 Endometrial Cancer trials
A listing of Endometrial Cancer medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.
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This is a randomized, open-label, global Phase 3 study designed to assess the effect of sacituzumab govitecan (SG) compared with TPC (doxorubicin or paclitaxel) in participants with recurrent/persistent endometrial cancer who have received prior treatment with platinum-based chemotherapy and anti-programmed cell death protein 1/programmed cell death ligand 1 (anti-PD-1/PD-L1) therapy. …
To assess safety and tolerability, including dose-limiting toxicities (DLTs), maximum tolerated dose (MTD), or maximum administered dose (MAD; if no MTD is defined) of IMGN151 when administered intravenouslyTo determine recommended Phase 2 dose (RP2D) for IMGN151To characterize the pharmacokinetics (PK) and immunogenicity of IMGN151 -To assess ORR for IMGN151 using …
This study investigates the effectiveness of adding investigational medication combinations to the usual chemotherapy in patients with HER2 positive endometrial cancer. The investigational medications, which include monoclonal antibodies like trastuzumab and pertuzumab, target HER2 receptors on cancer cells to block signals for growth and potentially mark the cells for destruction …
This study investigates the treatment of advanced or recurrent endometrial cancer with proficient mismatch repair (pMMR). In pMMR endometrial cancer, certain normal proteins are present in the cancer cells. This condition can be advanced, meaning the cancer has spread beyond the uterus, or recurrent, meaning it has returned after treatment. …
This study investigates an imaging technique using an investigational medication and a special camera system to detect cancer in patients undergoing surgery for endometrial cancer. The purpose of this study is to assess how well the investigational medication works when used with this imaging technique during surgery.Participants will undergo several …
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This study is divided into 2 parts (Escalation and Expansion). Your study doctor or study staff will also let you know you in what part of the study you will participate.The purpose of Part 1 (Escalation) of the study is to find the highest, safe dose of the study drug(s), …
This study investigates an investigational medication designed to treat patients with advanced or metastatic solid tumors. The purpose of the study is to evaluate the safety, tolerability, pharmacokinetics, and preliminary efficacy of this medication both as a standalone treatment and in combination with other agents. The study is focused on …
This study investigates the safety and tolerability of an investigational medication in patients with advanced solid tumors and lymphomas. The study is divided into two phases: Phase 1 focuses on finding the maximum tolerated dose of the investigational medication, while Phase 2 evaluates its antitumor activity across different types of …
This study investigates a DNA screening technique to detect colorectal cancer in patients with Lynch syndrome. The purpose of this study is to evaluate how well a specific DNA test, called the multitarget stool DNA (mt-sDNA) 2.0 test, works in identifying colorectal cancer in these patients.Participants in this study will …
This study investigates how genetic testing can guide cancer treatment choices for patients with advanced solid tumors. The purpose is to use the genetic information from patients' tumor cells to match them with investigational combination therapies that target specific genetic mutations. This approach aims to control tumor growth and improve …
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