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Found 10 Menopause trials

A listing of Menopause medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

Investigation of Social and Circadian Rhythm Dysregulation in the Development of Depression Symptoms During the Menopause Transition

45-52 years
Accepts healthy volunteer
Female
The purpose of this study is to examine how depression symptoms develop when women begin the transition to menopause. This study will investigate depression symptoms by looking at how fluctuations in reproductive hormones (specifically, the hormone estradiol) might impact the body's biological sleep rhythms. This study will also look at …
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A Double-Blinded Randomized Crossover Trial of Stereoencephalography-Guided Multi-Lead Deep Brain Stimulation for Treatment-Refractory Obsessive Compulsive Disorder (SEEG-Guided DBS for OCD)

22-75 years
All genders
Phase 1
This dual-site, double-blinded, randomized, sham-controlled, crossover study is to assess the safety, feasibility, and preliminary efficacy of SEEG-guided multi-lead DBS in 10 participants suffering from severe symptoms of chronic, treatment-refractory OCD. Stage 1: Invasive SEEG Monitoring and Recovery Goal: To perform stimulation mapping studies and SEEG recordings, that aid in …
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Randomized Blinded Discontinuation Trial of Ocrelizumab in Early Relapsing Multiple Sclerosis

99 years and younger
All genders
Phase 4
The primary study objective is to evaluate the rate of durable remission of relapsing disease activity, assessed serially both clinically and by MRI, from randomization through 48 months in participants with early relapsing multiple sclerosis who discontinue OCR after 12 and 24 months of treatment. Secondary objectives include: - Mechanistic: …
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Assist

99 years and younger
All genders
The purpose of this study is to evaluate the safety and efficacy of atrasentan vs placebo while on background therapy with SGLT2i in subjects with IgAN. The primary efficacy assessment is the change from baseline in proteinuria at week 12. Individual subject participation duration: up to 64 weeks for subjects …
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Rapport

99 years and younger
All genders
All objectives are listed in section 3 of the protocol, but the primary objective is to demonstrate that RAP-219 is effective in reducing frequency of RNS- recorded long episodes in participants with focal onset seizures. The primary endpoint is the change in RNS long episode frequency during the second 4-week …
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Cartesian MG-001

99 years and younger
All genders
Please refer to section 3 of the study protocol. Penn will only enroll participants into Part 3 of the study. PRIMARY OBJECTIVES The primary objective of Part 1 is to assess the safety, tolerability, and manufacturing feasibility of Descartes-08 in patients with GMG. Part 1 of the study follows an …
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The SAK HFpEF Trial

99 years and younger
All genders
1.Compare the impact on submaximal exercise endurance of Empa, with and without KNO3, as compared to active control (Potassium Chloride, KCl).2.Assess the impact of Empa, with and without KNO3, on SkM OxPhos using novel in vivo MRI-based imaging techniques that quantify SkM OxPhos and intramuscular perfusion with exercise3.Assess the impact …
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Biohaven Rise 2

99 years and younger
All genders
Primary Objective: To compare the efficacy of 2 doses of BHV-7000 to placebo as an adjunctive therapy for refractory focal onset epilepsy as measured by the change from baseline in 28-day average seizure frequency. Secondary Objcetives: -To compare the efficacy of 2 doses of BHV-7000 to placebo as adjunctive therapy …
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GE 280-401

99 years and younger
All genders
Primary Objective: a) To measure the proportion of breast cancer patients where Cerianna positron emission tomography (PET)/computed tomography (CT) detection of estrogen receptor (ER) status alters the preexamination intended therapeutic management Secondary Objectives: a) Per subject, to qualitatively assess heterogeneity in tumor Cerianna uptake relative to standard-of-care imaging b) Per …
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An Evaluation of Maintenance Therapy Combination Mirvetuximab Soravtansine and Olaparib (UPROAR)

18 years and older
Female
Phase 2
This study aims to learn more about the use of Mirvetuximab soravtansine and Olaparib as a maintenance therapy after completion of prior therapy for recurrent platinum sensitive ovarian, peritoneal and fallopian tube cancer. Mirvetuximab soravtansine is an effective antibody drug conjugate that targets folate receptor alpha. Olaparib is one of …
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