Found 19 Depression trials
A listing of Depression medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.
Families play an important role in the experiences of patients with chronic illnesses, including chronic obstructive pulmonary disease (COPD). This study aims to identify how an evidence-based coping skills training program, where patients and a support person work together to manage and overcome disease-related distress, can reduce depression and anxiety …
The purpose of this study is to examine how depression symptoms develop when women begin the transition to menopause. This study will investigate depression symptoms by looking at how fluctuations in reproductive hormones (specifically, the hormone estradiol) might impact the body's biological sleep rhythms. This study will also look at …
This research study is being conducted to learn more about how brain stimulation [transcranial magnetic stimulation (TMS)] affects the communication between brain regions. TMS is a new treatment that is starting to be used to treat depression and other psychiatric disorders. However, we do not have a good idea for …
Pilot Study: Establishing Glutamatergic Changes in Rapid Antidepressant Effects of Sleep Deprivation
This study aims to determine what underlies the antidepressant effects of sleep deprivation. A novel measure of glutamate imaging, GluCEST, will be used to assess changes in glutamatergic activity following total sleep deprivation.
The purpose of this study is to investigate the responses of the brain region known as the subgenual anterior cingulate cortex (sgACC) during transcranial magnetic stimulation (TMS) in individuals with depression. Specifically, investigators aim to determine whether the sgACC is engaged when TMS is delivered to specific targets and if …
In this trial, we will use an accelerated TMS protocol that concentrates the magnetic stimulation that would usually occur over 6 weeks into 10 treatment sessions per days, for 5 consecutive days in patient with treatment-refractory depression. This protocol will build on a published study (Williams et al., 2018) demonstrating …
This study’s goal is to identify and validate a package of implementation strategies to promote reach, effectiveness, adoption, implementation and maintenance of ASIST among Suicide Intervention Officers (SIO) in the Connecticut Army National Guard. Aim 1: Finalize our formative research to develop the implementation package for SIOs and chaplains. Hypothesis …
This dual-site, double-blinded, randomized, sham-controlled, crossover study is to assess the safety, feasibility, and preliminary efficacy of SEEG-guided multi-lead DBS in 10 participants suffering from severe symptoms of chronic, treatment-refractory OCD. Stage 1: Invasive SEEG Monitoring and Recovery Goal: To perform stimulation mapping studies and SEEG recordings, that aid in …
The primary objective of this study is to determine if treatment of the femoral head with core decompression and cell grafting increases the survivorship of the hip when compared to core decompression alone. The secondary objectives are to determine which factors may contribute to the success or failure of these …
The research study is being conducted to study brain patterns of negative emotion and develop personalized brain stimulation protocols to disrupt these patterns with transcranial magnetic stimulation (TMS). First, we will use functional Magnetic Resonance Imaging (fMRI) data to generate a negative affect map for each subject. Then, we will …
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