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Found 8 obstetrics-and-gynecology trials

A listing of obstetrics-and-gynecology medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

A Study of ZN-c3 in Subjects With High-Grade Serous Ovarian, Fallopian Tube or Primary Peritoneal Cancer

18 years and older
All genders
The purpose of this study includes the following: ·         To test the efficacy and safety of the Study Drug and to find out what effects, good and/or bad, it has on you and your cancer. ·         To understand how the body absorbs and processes the Study Drug by measuring the …
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Testing Different Amounts of the Combination of Drugs M1774 and ZEN-3694 for the Treatment of Recurrent Ovarian and Endometrial Cancer (NRG-GY031)

18-99 years
Female
Phase 1
To determine the maximum tolerated dose (MTD) and the dose-limiting toxicities (DLTs) for combination of ATR inhibitor (M1774) and BET inhibitor (ZEN003694) in women with recurrent clear cell, endometrioid, and platinum resistant high grade serous ovarian carcinoma (HGSOC) and clear cell and endometrioid endometrial carcinoma irrespective of ARID1A status.The target …
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A study of ceralasertib (AZD6738) as monotherapy and in combination with other anticancer agents in patients with advanced solid malignancies Module 5 (ceralasertib in combination with AZD5305) (ANGEL)

18-99 years
Female
Penn Gynecologic Oncology is participating in Module 5 for ovarian cancer patients.
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Letrozole With or Without Paclitaxel and Carboplatin in Treating Patients With Stage II-IV Ovarian, Fallopian Tube, or Primary Peritoneal Cancer

Female
Phase 3
This phase III trial studies how well letrozole with or without paclitaxel and carboplatin works in treating patients with stage II-IV low-grade serous carcinoma of the ovary, fallopian tube, or peritoneum. Letrozole is an enzyme inhibitor that lowers the amount of estrogen made by the body which in turn may …
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A Trial of Robotic Versus Open Hysterectomy Surgery in Cervix Cancer (ROCC)

18 years and older
Female
The purpose of this study is to investigate if minimally invasive surgery, called robotic assisted laparoscopy (small incision surgery), is better or worse than open surgery (otherwise known as a laparotomy) when performing a radical hysterectomy for cervical cancer. A radical hysterectomy is surgery to remove the uterus, cervix, the …
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GEN1047 for Solid Tumors (GENMAB)

18-99 years
Female
Phase 1/2
The overall objective of the study is to determine the maximum tolerated dose/maximum administered dose and to characterize the safety profile of GEN1047. The primary outcome variables are, dose limiting toxicities, adverse events and safety laboratory parameters as well as objective response rate based on RECIST v1.1. The secondary outcome …
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MVT-601A-006 MOXIE

99 years and younger
All genders
The primary objective of this study is to characterize changes in bone mineral density (BMD) during continuous treatment with relugolix combination tablet (relugolix 40 mg/estradiol [E2] 1 mg/norethindrone acetate [NETA] 0.5 mg) for up to 48 months (4 years) in two cohorts: (1) premenopausal women with heavy menstrual bleeding associated …
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A Phase 3, Multicenter, Open-Label, Randomized Study of Nemvaleukin Alfa in Combination with Pembrolizumab Versus Investigator’s Choice Chemotherapy in Patients with Platinum-Resistant Epithelial Ovarian, Fallopian Tube, or Primary Peritoneal Cancer (ARTISTRY-7)

18 years and older
Female
Phase 3
Purpose of the Study The purpose of this study is to find answers to the following research questions: ·         How effective is nemvaleukin alone and in combination with pembrolizumab in treating your epithelial ovarian, fallopian tube, or primary peritoneal cancer compared with chemotherapy? ·         What effect does nemvaleukin alone and …
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