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Found 13 dm-translational-medicine-and-human-genetics trials
A listing of dm-translational-medicine-and-human-genetics medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.
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The primary objective is to evaluate the efficacy of obicetrapib alone for 8 weeks as compared to obicetrapib in combination with Evolocumab for an additional 8 weeks after initial obicetrapib treatment on percent change of Lp(a) levels from Baseline in people with mild dyslipidemia, defined as Lp(a) levels 50 mg/dL …
This study investigates idiopathic Multicentric Castleman Disease (iMCD).The study evaluates the effects of an investigational medication on iMCD symptoms and how well it is tolerated by participants.Who can participate: Adults aged 18 to 80 with a history of iMCD can participate. Key eligibility includes documented disease history, not responding to …
This study investigates cardiovascular events in individuals with elevated lipoprotein(a).It evaluates the effect of an investigational medication on the risk of heart disease-related death and other major heart events.Who can participate: Adults aged 50 and older with high lipoprotein(a) levels can participate.Study details: Participants will receive either the investigational medication …
Requesting a reliance agreement with an external IRB. The purpose of this open-label extension trial is to evaluate the long-term safety and efficacy of treatment with plozasiran on the reduction of fasting serum TG from Baseline in subjects with Severe Hypertriglyceridemia.
Requesting a reliance agreement with an external IRB. The objectives are to evaluate the long-term safety and tolerability of pelacarsen (TQJ230) in participants with elevated Lp(a) and established CVD who have completed the parent Lp(a)HORIZON study, evaluate the long-term efficacy of pelacarsen (TQJ230) on 4P-MACE, and to evaluate the long-term …
The study is a clinical trial open to people who require additional lowering of low-density lipoprotein cholesterol (LDL-C) and who also have a genetic condition called heterozygous familial hypercholesterolemia (HeFH) and/or evidence of premature coronary artery disease (CAD). Premature CAD is the narrowing or blockage of arteries that supply the …
This study aims to identify how useful polygenic and integrated risk is in both helping doctors to treat and manage their patients, and identifying people at risk of developing coronary artery disease. Targeted population is previously genotyped individuals in the PMBB. We will calculate an integrated risk score for coronary …
TBD
The objectives of the study are to recruit patients with tumors of the autonomic nervous system and develop an annotated database including tissue samples to facilitate research with the goal of better understanding the genetics and biochemical signaling pathways leading to tumor formation and malignancy. The primary goal of this …
The purpose of this protocol is to send the pre-collected and shelved DNA samples (parent protocol IRB #376800) from patients fitting the study eligibility requirements for genotyping at the Center for Inherited Disease Research (CIDR) at Johns Hopkins University. The samples will be used in genome-wide association studies (GWAS), which …
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