Found 15 op-ophthalmology trials
A listing of op-ophthalmology medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.
This study seeks to find out whether an oral medication called Fenofibrate can slow or prevent worsening of diabetic retinopathy.
Currently, this study is recruiting among patients at Penn Medicine. It is not accepting non-Penn Medicine patient participants.The objective of the study will be to evaluate the efficacy and safety of oral N-acetylcysteine (NAC) in patients with retinitis pigmentosa (RP). The study is a multi-center, randomized, placebo-controlled study where adult …
To evaluate the safety and tolerability of OPGx-001 administered via subretinal injection to one eye (treated eye) of participants with LCA5-IRD. The safety and tolerability as assessed by: 1. Number of dose limiting toxicity (DLT) events at the proposed doses 2. Number of procedure-related adverse events (AEs) 3. Number and …
Patients with an epiretinal membrane (ERM) are either referred for vitrectomy, or if their vision is normal are deferred until vision declines. It is unknown if delaying surgery results in worse visual acuity than if surgery is performed earlier. Additionally, a common symptom from an ERM is metamorphopsia. The objective …
This study will investigate the safety and efficacy of VRDN-001 in participants who were non-responders as defined in either the VRDN-001-101 or VRDN-001-301 pivotal studies.
The purpose of this study is to assess the efficacy, safety, pharmacokinetics, and pharmacodynamics of subcutaneous satralizumab, a recombinant, humanized antiinterleukin-6 (IL-6) receptor monoclonal antibody, in participants with moderate-to-severe thyroid eye disease (TED).
This phase 3, partially masked, randomized, multicenter study will include 2 periods: an Active Run-in Period (ie, Screening) and an Assessment Period. Participants who receive RGX-314 will be provided the opportunity to enroll into a long-term follow-up (LTFU) study (RGX-314-5101) after completion of or early discontinuation from this current study …
Gyrate atrophy (GA) is a rare inherited chorioretinal degeneration that is associated with hyperornithinemia, an inborn error of metabolism caused by autosomal recessive mutations in the ornithine aminotransferase (OAT) gene. The current standard care treatment of GA is an arginine restricted diet. To facilitate a future interventional gene therapy clinical …
Patients with nAMD most commonly receive an anti-VEGF injection into the eye. A "Treat and Extend" method is used to determine how often injections are needed. OCT scans of the eye are used to determine when to give treatment. This study seeks to see how using a Home OCT device …
PURPOSE The goal of this study is to measure the levels of over 11,000 proteins in the aqueous humor and correlate it with single-cell transcriptomics data. This will improve understanding of the molecular mechanisms and cell types contributing to dry AMD, POAG, and Stargardts disease. This will allow us to …
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