Found 10 oncology trials
A listing of oncology medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.
A study of ceralasertib (AZD6738) as monotherapy and in combination with other anticancer agents in patients with advanced solid malignancies Module 5 (ceralasertib in combination with AZD5305) (ANGEL)
Penn Gynecologic Oncology is participating in Module 5 for ovarian cancer patients.
Letrozole With or Without Paclitaxel and Carboplatin in Treating Patients With Stage II-IV Ovarian, Fallopian Tube, or Primary Peritoneal Cancer
Phase 3
This phase III trial studies how well letrozole with or without paclitaxel and carboplatin works in treating patients with stage II-IV low-grade serous carcinoma of the ovary, fallopian tube, or peritoneum. Letrozole is an enzyme inhibitor that lowers the amount of estrogen made by the body which in turn may …
Combination ATR and PARP Inhibitor (CAPRI) trial with AZD6738 and Olaparib in recurrent ovarian cancer
Phase 2
This project studies combination AZD6738 and olaparib (Lymparza) to treat recurrent ovarian cancer. It will examine 1) the safety and tolerability of this drug combination and 2) the overall response rate (tumor strinkage rate) of this therapy. All study patients have recurrent ovarian cancer. None of the patients have standard …
A Study of ZN-c3 in Subjects With High-Grade Serous Ovarian, Fallopian Tube or Primary Peritoneal Cancer
The purpose of this study includes the following: · To test the efficacy and safety of the Study Drug and to find out what effects, good and/or bad, it has on you and your cancer. · To understand how the body absorbs and processes the Study Drug by measuring the …
A Trial of Robotic Versus Open Hysterectomy Surgery in Cervix Cancer (ROCC)
The purpose of this study is to investigate if minimally invasive surgery, called robotic assisted laparoscopy (small incision surgery), is better or worse than open surgery (otherwise known as a laparotomy) when performing a radical hysterectomy for cervical cancer. A radical hysterectomy is surgery to remove the uterus, cervix, the …
GEN1047 for Solid Tumors (GENMAB)
Phase 1/2
The overall objective of the study is to determine the maximum tolerated dose/maximum administered dose and to characterize the safety profile of GEN1047. The primary outcome variables are, dose limiting toxicities, adverse events and safety laboratory parameters as well as objective response rate based on RECIST v1.1. The secondary outcome …
A Study of CPI-0209 in Patients with Advanced Solid Tumors and Lymphomas (CPI 0209)
Phase 1/2
First-in-human, open-label, sequential dose escalation and expansion study of CPI-0209 in patients with advanced solid tumors and lymphomas. CPI-0209 is a small molecule inhibitor of EZH2.
A Study to Compare Two Surgical Procedures in Individuals with BRCA1 Mutations to Assess Reduced Risk of Ovarian Cancer (SOROCk- NRG-CC008)
The purpose of this study is to determine if two surgical procedures, the usual approach of removing the fallopian tubes and ovaries and the other approach of removing the fallopian tubes at this time with the plan to remove the ovaries at a later time, are no different for ovarian …
A Study of XmAb20717 (Vudalimab)in Patients With Selected Advanced Gynecologic and Genitourinary Malignancies (Xencor)
Phase 2
The purpose of the study is to assess whether an investigational drug, called XmAb20717, has any effects on certain types of cancers and if it is safe and well tolerated.
A Phase 3, Multicenter, Open-Label, Randomized Study of Nemvaleukin Alfa in Combination with Pembrolizumab Versus Investigator’s Choice Chemotherapy in Patients with Platinum-Resistant Epithelial Ovarian, Fallopian Tube, or Primary Peritoneal Cancer (ARTISTRY-7)
Phase 3
Purpose of the Study The purpose of this study is to find answers to the following research questions: · How effective is nemvaleukin alone and in combination with pembrolizumab in treating your epithelial ovarian, fallopian tube, or primary peritoneal cancer compared with chemotherapy? · What effect does nemvaleukin alone and …
