Found 25 cardiology trials
A listing of cardiology medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.
The purpose of this study is to characterize the differences in the aortic valve and aortic root anatomy in patients with BAVs in order to better understand the anatomical features that allow the BAV to function normally. With this information, surgeons and cardiologists will be better able to determine which …
This study will focus on fat buildup inside the heart muscle, a newly recognized factor that makes patients vulnerable to such fast heart rates, or ventricular tachycardia, after a heart attack. This work may identify more successful strategies for curing dangerously fast heart rates. Adult subjects with prior history of …
This study will determine if ziltivekimab, a monoclonal antibody, can be used to treat people living with heart failure and inflammation. Previous studies showed that ziltivekimab can lower inflammation, which may have a positive effect on heart failure symptoms. The HERMES study will look more into this effect. Also, the …
The OPTIMIZER Smart Post-Approval Study (PAS) is a single arm open label study of 620 participants receiving an OPTIMIZER implant as standard of care. Patients to be included will have NYHA functional class III symptoms and a left ventricular ejection fraction of 25-45%.
This research study seeks to validate how echocardiogram (echo) data predicts response to cardiac resynchronization therapy (CRT) provided by a CRT device with a defibrillator (CRT-D) in individuals without the heart arrhythmia abnormality left bundle branch block (LBBB). It also aims to identify new variables recorded from electrocardiograms (ECG) or …
This is a prospective global multicenter long-term observational study designed to document the clinical outcomes of patients with hereditary transthyretin-mediated amyloidosis or wild-type transthyretin-mediated amyloidosis and the safety of patisiran (Onpattro) when used in patients with ATTRv amyloidosis. This is data collection study only and no study medication no visits …
This open-label study is designed to evaluate the long-term safety and tolerability of acoramidis in participants with ATTR-CM, administered on a background of stable heart failure therapy. This study follows the randomized, double-blind, placebo-controlled Study AG10-301 which was designed to examine safety and efficacy in this same population.
This study is a prospective, multicenter, randomized controlled trial of the FlowTriever System plus anticoagulation compared to anticoagulation alone for intermediate-risk acute PE. Up to 1200 subjects with intermediate-risk acute PE will be randomized. All subjects who sign informed consent and who meet all of the inclusion criteria and none …
This is a multicenter, randomized, quadruple-blind, sham controlled, 2-part, embedded IDE clinical trial. The main objective is to evaluate the efficacy and safety of Cardiac Contractility Modulation (CCM) therapy in patients with symptomatic HF with LVEF 40-60%. The study is divided into 3 phases, screening, randomization (where 2/3 will be …
The INTEGRA D study will evaluate the safety and efficacy of the CCM D System in patients with heart failure symptoms despite being on GDMT and have an LVEF 40%.The This is designed as a single arm, prospective, multicenter study of 300 subjects that will establish that the device can …
